PCV3 - IMPROVING ASPIRIN TOXICITY THROUGH PRECISION MEDICINE

Improving drug sensitivity predictions in precision medicine through active expert knowledge elicitation

Predicting the efficacy of a drug for a given individual, using highdimensional genomic measurements, is at the core of precision medicine. However, identifying features on which to base the predictions remains a challenge, especially when the sample size is small. Incorporating expert knowledge offers a promising alternative to improve a prediction model, but collecting such knowledge is labor...

Precision medicine, technologies, and molecular diagnostics

Introduction: Genetics, cellular and molecular medicines are cutting-edge sciences and technologies that play an important role in improving human health and quality of life. In addition, medical and biological sciences have clearly shown that the onset of diseases differs from person to person due to their different genetic profiles and variations in molecular basis. Therefore, it is feasible ...

Improving precision medicine using individual patient data from trials.

© 2016 Joule Inc. or its licensors CMAJ 1 Our first commitment as clinicians is to our patients as individuals. This understanding lies at the heart of the precision medicine initiative, which aims to customize treatments based not only on a patient’s clinical picture but also on their genetic, demographic and environmental profile.1 Clinical trials are rigid by design, typically assessing the ...

Precision Chemistry for Precision Medicine

During the 2015 State of the Union address, President Obama unveiled plans for a $215 million Precision Medicine Initiative. The details of this plan were laid out by past and present directors of the National Institutes of Health, Harold Varmus and Francis Collins, in a commentary in the New England Journal of Medicine. While the announcement stood as a public statement of support for funding,...

Precision Medicine